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Sulforaphane promotes diabetic wound healing by regulating macrophage efferocytosis and polarization

This includes the key transcription factor nuclear factor kappa B (NF-B), which triggers the infiltration of inflammatory cells in the pancreas and systemic inflammatory response, leading to acinar cell death through apoptosis and necrosis (9)

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As the sole intracellular LPO-reducing enzyme, the lack of GPX4 results in excessive accumulation of LPO, destabilizing biological membranes, exacerbating oxidative stress, and ultimately promoting ferroptosis (Ursini and Maiorino, 2020)

Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice [J]